Reelin Glycoprotein

Reelin Glycoprotein Author S.H. Fatemi
ISBN-10 9780387767611
Release 2008-06-04
Pages 443
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Reelin glycoprotein is a serine protease with important roles in embryogenesis and during adult life. This comprehensive and integrative book examines the role that reelin plays in the etiology of various neuropsychiatric disorders, including schizophrenia and autism. The book provides an unprecedented analysis of this emerging and novel protein by examining evidence from genetic, neuroanatomic, biochemical, and behavioral studies.


Glycoproteins Author Source Wikipedia
ISBN-10 1157451624
Release 2010-09
Pages 372
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Please note that the content of this book primarily consists of articles available from Wikipedia or other free sources online. Pages: 83. Chapters: Antibody, Reelin, Glycoprotein, Perlecan, Osteopontin, Major histocompatibility complex, Lacritin, Human chorionic gonadotropin, Glycophorin C, Nucleoporin 62, Glycoprotein 130, Polyclonal antibodies, Envelope glycoprotein GP120, Versican, Lectin, Follicle-stimulating hormone, Alpha-fetoprotein, Myelin oligodendrocyte glycoprotein, Tamm-Horsfall protein, PRG4, Intravenous immunoglobulin, Luteinizing hormone, CD4, Avidin, Dystroglycan, Immunoglobulin E, Synaptophysin, Sex hormone-binding globulin, Cysteine-rich secretory protein, Uteroglobin, MHC class I, Thyroid-stimulating hormone, Tenascin X, Agrin, Osteonectin, Immunoglobulin A, Immunoglobulin G, CD1D, Nicotinamide riboside, Immunoglobulin M, Nucleoporin 210kDa, E-selectin, Proteoglycan, Immunoglobulin D, Extensin, Entactin, MHC class II, Tumor-associated glycoprotein 72, Immunoglobulin Y, Primary and secondary antibodies, Gliadin, Orosomucoid, Immunofixation, Gp41, Glutelin, Peanut agglutinin, Androgen-binding protein, Transcortin, Glomalin, SIBLING proteins, Sequon, Hordein, Glutenin, Mammaglobin, Draculin, CD32B, Prolamin, Leucocyte common antigen, Secalin, Ependymin, Astrotactin, Sialoglycoprotein, Membrane glycoproteins, Mucoprotein, Alvircept sudotox, Dog leukocyte antigen. Excerpt: Reelin is a protein that helps regulate processes of neuronal migration and positioning in the developing brain. Besides this important role in early development, reelin continues to work in the adult brain. It modulates the synaptic plasticity by enhancing the induction and maintenance of long-term potentiation. It also stimulates dendrite and dendritic spine development and regulates the continuing migration of neuroblasts generated in adult neurogenesis sites like subventricular and subgranular zones. It is found not only in the brain, but also in the spinal cord, blood, and ...

The Neurobiology of Autism

The Neurobiology of Autism Author Margaret L. Bauman
ISBN-10 0801880475
Release 2005
Pages 404
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For this long-anticipated new edition, neurologists Margaret L. Bauman and Thomas L. Kemper bring together leading researchers and clinicians to present the most current scientific knowledge and theories about autism. "Anyone doing research in autism or other developmental disorders will find this an invaluable book to read to make sure all areas are understood and to serve as a rich source of references." -- American Journal of Psychiatry

Psychiatry 2 Volume Set

Psychiatry  2 Volume Set Author Allan Tasman
ISBN-10 9781118753361
Release 2015-02-05
Pages 2768
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Now in a new Fourth Edition, Psychiatry remains the leading reference on all aspects of the current practice and latest developments in psychiatry. From an international team of recognised expert editors and contributors, Psychiatry provides a truly comprehensive overview of the entire field of psychiatry in 132 chapters across two volumes. It includes two new sections, on psychosomatic medicine and collaborative care, and on emergency psychiatry, and compares Diagnostic and Statistical Manual (DSM-5) and International Classification of Diseases (ICD10) classifications for every psychiatric disorder. Psychiatry, Fourth Edition is an essential reference for psychiatrists in clinical practice and clinical research, residents in training, and for all those involved in the treatment psychiatric disorders. Includes a a companion website at featuring PDFs of each chapter and downloadable images

The neocortical column

The neocortical column Author Javier DeFelipe
ISBN-10 9782889190423
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The columnar organization is currently the most widely held hypothesis to explain the cortical processing of information, making its study of potential interest to any researcher interested in the cerebral cortex, both in a healthy and pathological state. Enough data are now available so that the Blue Brain Project can realistically tackle a model of the sensory column in rat. Few will deny however, that a comprehensive framework of the function and structure of columns has remained elusive. One set of persistent problems, as frequently remarked, is nomenclature. "Column" is used freely and promiscuously to refer to multiple, distinguishable entities; for example, cellular or dendritic minicolumns (<50um), and afferent macrocolumns (200-500um). Another set of problems is the degree to which the classical criteria (shared response properties, shared input and common output) may need to be modified and, if so, how. A third, related set of problems is to define area-specific and species-specific variations. Finally, more of an ultimate goal than a problem, is to achieve fundamental understanding of what columns are and how they are used in cortical processes. Therefore, one of the major objectives is to translate recent technical advances and new findings in the neurosciences into practical applications for the neuroscientist, the clinician, and for those interested in comparative anatomy and brain evolution.

New Concepts of Psychostimulants Induced Neurotoxicity

New Concepts of Psychostimulants Induced Neurotoxicity Author Hari Shanker Sharma
ISBN-10 0080922902
Release 2009-11-05
Pages 472
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Published since 1959, International Review of Neurobiology is a well-known series appealing to neuroscientists, clinicians, psychologists, physiologists, and pharmacologists. Led by an internationally renowned editorial board, this important serial publishes both eclectic volumes made up of timely reviews and thematic volumes that focus on recent progress in a specific area of neurobiology research. With recent advancements in new knowledge, it has become evident that psychostimulants and related drugs of abuse are influencing our central nervous system (CNS) remarkably and could alter their function for a longtime. This volume is the first to focus on substance abuse induced brain pathology in the widest sense as it covers alterations in neuronal, glial and endothelial cell functions under the influence of acute or chronic usage of substance abuse.

Novel Approaches to Studying Basal Ganglia and Related Neuropsychiatric Disorders

Novel Approaches to Studying Basal Ganglia and Related Neuropsychiatric Disorders Author XIAO-HONG LU
ISBN-10 0080953875
Release 2009-11-06
Pages 195
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Published since 1959, International Review of Neurobiology is a well-known series appealing to neuroscientists, clinicians, psychologists, physiologists, and pharmacologists. Led by an internationally renowned editorial board, this important serial publishes both eclectic volumes made up of timely reviews and thematic volumes that focus on recent progress in a specific area of neurobiology research. This volume is a collection of articles covering Novel Approaches to Studying Basal Ganglia and Related Neuropsychiatric Disorders. Topics covered include molecular profiling of direct and indirect striatal medium spiny neurons, the role of epigenetics in development and function of basal ganglia and transgenic animal models for Parkinson's disease.

Molecular Mechanisms of Synaptogenesis

Molecular Mechanisms of Synaptogenesis Author Alexander Dityatev
ISBN-10 9780387325620
Release 2006-11-24
Pages 497
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This book provides a new compilation of information that link changes in the basic structure of synapses and brain diseases. The book shows that specific secreted proteins, and short peptide mimicking the function of neural cell adhesion molecules can significantly enhance the formation of synapses in the brain. It describes recent advances in research that lay necessary scientific groundwork to develop pharmacological treatments.

Issues in Neuroscience Research and Application 2011 Edition

Issues in Neuroscience Research and Application  2011 Edition Author
ISBN-10 9781464963605
Release 2012-01-09
Pages 3141
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Issues in Neuroscience Research and Application: 2011 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Neuroscience Research and Application. The editors have built Issues in Neuroscience Research and Application: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Neuroscience Research and Application in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Issues in Neuroscience Research and Application: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at

Reelin signaling pathway and its contributions to nociceptive processing

Reelin signaling pathway and its contributions to nociceptive processing Author Alin Lina Akopians
ISBN-10 UCLA:L0096928692
Release 2006
Pages 116
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The reeler gene encodes Reelin, a large secreted extracellular matrix-type glycoprotein, that has an important role in neuronal migration. Reelin binding to the very low density lipoprotein (Vldl) and apolipoprotein E2 (Apoe2) receptors induces Src- and Fyn-mediated tyrosine phosphorylation of Disabled-1 (Dab1). This Reelin-Dab1 pathway regulates downstream signaling events that influence the location and orientation of specific neuronal populations during development. Initially we identified a significant reduction in mechanical sensitivity in reeler mice and a pronounced thermal hyperalgesia. We also observed an aberrant neuronal compaction in lamina I of the dorsal horn and reduced numbers of lateral spinal nucleus (LSN) neurons in reeler mutants. Furthermore, we detected incorrectly positioned Dab1-positive neurons in reeler laminae I-II that bear the neurokinin-1 (NK-1) receptor, an established target of the substance P population of nociceptors. We then tested mice with mutations in the Dab1 protein or the single Reelin receptor knockouts (Vldlr-/- and Apoer2-/-). Dab1 and scrambler (natural Dab1 hypomorph) mutants also are insensitive to mechanical nociception and thermal hyperalgesia compared with controls, findings that parallel our results in reeler mice. In contrast, the single receptor knockouts do not differ in either mechanical or thermal sensitivity compared to wild-type controls. We detected a 40-60% reduction of LSN neurons throughout the Dab l and scrambler spinal cords, but Vldlr-/- , Apoer2-/- and their respective controls have equivalent number of LSN neurons. Dab1 and scrambler mutants, not the Vldlr-/- , Apoer2 or control mice, also contain NK-1-positive neurons in lamina II, an area normally devoid of these neurons. We conclude that the Reelin-Dab1 signaling pathway contributes to neuronal positioning within the superficial dorsal horn and LSN and that deletion of either the first or the third component of the signaling pathway significantly alters both thermal and mechanical nociceptive processing.

Fanaroff and Martin s Neonatal Perinatal Medicine

Fanaroff and Martin s Neonatal Perinatal Medicine Author Richard J. Martin
ISBN-10 9780323295376
Release 2014-08-20
Pages 1936
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Tackle your toughest challenges and improve the quality of life and long-term outcomes of your patients with authoritative guidance from Fanaroff and Martin s Neonatal-Perinatal Medicine. Drs. Richard J. Martin, Avroy A. Fanaroff, and Michele C. Walsh and a contributing team of leading experts in the field deliver a multi-disciplinary approach to the management and evidence-based treatment of problems in the mother, fetus and neonate. New chapters, expanded and updated coverage, increased worldwide perspectives, and many new contributors keep you current on the late preterm infant, the fetal origins of adult disease, neonatal anemia, genetic disorders, and more. "...a valuable reference book and a pleasure to read." Reviewed by BACCH Newsletter, Mar 2015 Consult this title on your favorite e-reader, conduct rapid searches, and adjust font sizes for optimal readability. Be certain with expert, dependable, accurate answers for every stage of your career from the most comprehensive, multi-disciplinary text in the field! See nuance and detail in full-color illustrations that depict disorders in the clinical setting and explain complex information. Obtain more global perspectives and best practices with contributions from international leaders in the field of neonatal-perinatal medicine. Get comprehensive guidance on treating patients through a dual focus on neonatology and perinatology. Spot genetic problems early and advise parents of concerns, with a completely new section on this topic. Make informed clinical choices for each patient, from diagnosis and treatment selection through post-treatment strategies and management of complications, with new evidence-based criteria throughout. Stay at the forefront of your field thanks to new and completely revised chapters covering topics such as: Principles and Practice l Immune and Non-immune Hydrops Fetalis l Amniotic Fluid Volume l Enhancing Safe Prescribing in the Neonatal Intensive Care Unit l Role of Imaging in Neurodevelopmental Outcomes of High-Risk Neonates l Patent Ductus Arteriosus l Gastroesophageal Reflux and Gastroesophageal Reflux Diseases in the Neonate. Find and grasp the information you need easily and rapidly with indexing that provides quick access to specific guidance.

Handbook of Pediatric Neuropsychology

Handbook of Pediatric Neuropsychology Author Andrew S. Davis, PhD
ISBN-10 0826157378
Release 2010-10-25
Pages 1400
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ìBy far, the most comprehensive and detailed coverage of pediatric neuropsychology available in a single book today, Davis provides coverage of basic principles of pediatric neuropsychology, but overall the work highlights applications to daily practice and special problems encountered by the pediatric neuropsychologist.î Cecil R. Reynolds, PhD Texas A&M University "The breadth and depth of this body of work is impressive. Chapters written by some of the best researchers and authors in the field of pediatric neuropsychology address every possible perspective on brain-behavior relationships culminating in an encyclopedic textÖ. This [book] reflects how far and wide pediatric neuropsychology has come in the past 20 years and the promise of how far it will go in the next." Elaine Fletcher-Janzen, EdD, NCSP, ABPdN The Chicago School of Professional Psychology " would be hard to imagine a clinical situation in pediatric neuropsychology in whichthis book would fail as a valuable resource."--Archives of Clinical Neuropsychology "I believe there is much to recommend this hefty volume. It is a solid reference that I can see appreciating as a resource as I update my training bibliography."--Journal of the International Neuropsychological Society This landmark reference covers all aspects of pediatric neuropsychology from a research-based perspective, while presenting an applied focus with practical suggestions and guidelines for clinical practice. Useful both as a training manual for graduate students and as a comprehensive reference for experienced practitioners, it is an essential resource for those dealing with a pediatric population. This handbook provides an extensive overview of the most common medical conditions that neuropsychologists encounter while dealing with pediatric populations. It also discusses school-based issues such as special education law, consulting with school staff, and reintegrating children back into mainstream schools. It contains over 100 well-respected authors who are leading researchers in their respective fields. Additionally, each of the 95 chapters includes an up-to-date review of available research, resulting in the most comprehensive text on pediatric neuropsychology available in a single volume. Key Features: Provides thorough information on understanding functional neuroanatomy and development, and on using functional neuroimaging Highlights clinical practice issues, such as legal and ethical decision-making, dealing with child abuse and neglect, and working with school staff Describes a variety of professional issues that neuropsychologists must confront during their daily practice, such as ethics, multiculturalism, child abuse, forensics, and psychopharmacology

GABA in Autism and Related Disorders

GABA in Autism and Related Disorders Author Dirk M. Dhossche
ISBN-10 0123668727
Release 2005
Pages 481
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Gamma-aminobutyric acid (GABA) was discovered in the brain in 1950 by Eugene Roberts. GABA is now considered one of the most important neurotransmitters and developmental signals. Knowledge on the complexity of GABA function is increasing exponentially. This volume covers basic research on GABA in the developing brain as it may relate to onset of autism and related developmental disorders. The evidence that dysfunction of GABA and related molecules is associated with autism is limited but expanding and seems to converge. Pertinent data are reviewed in this book and new research avenues in the basic and clinical arenas are described. The topics are of imminent interest to basic and clinical researchers as well as interested clinicians. * Discusses the neuropathology of the GABA system in autism * Presents new findings on common genetic mechanisms in Rett syndrome, Angelman syndrome, and autism * Includes information on the shared genetic risk factors between autism and major mental disorders * Foreword by Eugene Roberts

The Postmortem Brain in Psychiatric Research

The Postmortem Brain in Psychiatric Research Author Agam Galila
ISBN-10 9781475736311
Release 2013-03-09
Pages 404
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Because of the dearth of experimental animal models of psychiatric disorders, the study of the effect of the disease state is only possible in tissue derived from patients vs. controls, especially in the target tissue of disease-related changes in the brain. The human postmortem brain offers the most appropriate experimental paradigm towards understanding the etiology of psychiatric disorders. The availability of post-mortem human samples from psychiatric patients and comparison groups in recent years has contributed prominently to the accumulating body of information leading to a better understanding of these disorders. This is the first book to summarize this research approach and the meaningful data which has recently been acquired.

The Hippocampus Book

The Hippocampus Book Author Per Andersen
ISBN-10 9780199880133
Release 2006-11-02
Pages 872
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The hippocampus is one of a group of remarkable structures embedded within the brain's medial temporal lobe. Long known to be important for memory, it has been a prime focus of neuroscience research for many years. The Hippocampus Book promises to facilitate developments in the field in a major way by bringing together, for the first time, contributions by leading international scientists knowledgeable about hippocampal anatomy, physiology, and function. This authoritative volume offers the most comprehensive, up-to-date account of what the hippocampus does, how it does it, and what happens when things go wrong. At the same time, it illustrates how research focusing on this single brain structure has revealed principles of wider generality for the whole brain in relation to anatomical connectivity, synaptic plasticity, cognition and behavior, and computational algorithms. Well-organized in its presentation of both theory and experimental data, this peerless work vividly illustrates the astonishing progress that has been made in unraveling the workings of the brain. The Hippocampus Book is destined to take a central place on every neuroscientist's bookshelf.

Reelin Signaling Promotes Radial Glia Maturation and Neurogenesis

Reelin Signaling Promotes Radial Glia Maturation and Neurogenesis Author Serene Keilani
ISBN-10 OCLC:794271711
Release 2009
Pages 116
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The end of neurogenesis in the human brain is marked by the transformation of the neural progenitors, the radial glial cells, into astrocytes. This event coincides with the reduction of Reelin expression, a glycoprotein that regulates neuronal migration in the cerebral cortex and cerebellum. A recent study showed that the dentate gyrus of the adult reeler mice, with homozygous mutation in the RELIN gene, have reduced neurogenesis relative to the wild type. Based on the above findings, our first hypothesis states that Reelin expression is important for the formation of radial glia and the generation of neurons from the neural progenitors. In order to investigate the role of Reelin in the process of cortical neurogenesis during development, we used human neural progenitor cells (hNPCs) that were isolated from a fetal cortex. These cells do not express Reelin. In this study, we show that Reelin addition to these hNPCs in vitro induced the formation of radial glia and increased neurogenesis significantly. Next, we investigated the mechanism by which Reelin increases the formation of radial glia and the generation of neurons. The formation of radial glia is under the control of two pathways, these are the Reelin and the Notch-1 signaling pathways. Since the level of Notch-1 activation determines if a cell would become a radial glia or an astrocyte, and since the absence of Reelin allows the transformation of a radial glia into astrocyte, we hypothesized that Reelin induces the formation of radial glia via activating Notch-1 signaling. To test this hypothesis, we investigated the effect of Reelin addition on Notch-1 activation in hNPCs. We found that Reelin addition in vitro activated Notch-1 signaling by increasing the level of Notch-1 intracellular domain (NICD). On the other hand, reducing NICD release, by inhibiting [gamma]-secretase activity, inhibited the Reelin-induced radial glia, confirming that Reelin's effect on the formation of radial glia is dependent on Notch-1 activation. Furthermore, we found that the Reelin-induced tyrosine phosphorylation of Disabled-1 (Dab-1), an adaptor protein downstream of Reelin, and the subsequent activation of Src family kinases, are essential steps for Notch-1 activation by Reelin. Finally, we found that Reelin addition increased the binding of Dab-1, recently identified as a nucleoshuttling protein, to NICD and enhanced NICD translocation to the nucleus. This resulted in the induction of BLBP expression and the subsequent formation of radial glia. Taken together, these data show that Reelin signaling, mediated by Dab-1 and Src kinase, activates Notch-1 signaling in hNPCs resulting in the induction of BLBP expression, the formation of radial glia and the generation of neurons. This work is novel because it provides that first evidence that Reelin expression is an important signal for the neuronal differentiation of the hNPCs. It also shows the crosstalk between Reelin and Notch-1 signaling, two major pathways in development and cell fate determination. The work is significant because it improves our understanding of the role of Reelin signaling in cell fate determination, differentiation and neurogenesis for the future manipulation of these processes to restore adult brain functions after brain injury or in neurodegenerative diseases.

WNTS are Guidance Cues in Anterior posterior Neuronal Migration

WNTS are Guidance Cues in Anterior posterior Neuronal Migration Author James Endres Howell
ISBN-10 UCAL:C3502616
Release 2005
Pages 302
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WNTS are Guidance Cues in Anterior posterior Neuronal Migration has been writing in one form or another for most of life. You can find so many inspiration from WNTS are Guidance Cues in Anterior posterior Neuronal Migration also informative, and entertaining. Click DOWNLOAD or Read Online button to get full WNTS are Guidance Cues in Anterior posterior Neuronal Migration book for free.